Cardiosulfa induces heart deformation in zebrafish through the AhR-mediated, CYP1A-independent pathway.
作者： Sung-Kyun Ko , Injae Shin
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摘要: Heart development is a complicated and elaborate biological process. To study this similar process diseases, the discovery use of small molecules for probing events invaluable. As part such an investigation, we have identified cardiosulfa, molecule that induces severely impaired heart morphology function in zebrafish. The results present show cardiosulfa-promoted deformation protected by negative regulators aryl hydrocarbon receptor (AhR) signaling pathway, as AhR antagonist CH-223191 AhR2-morpholino antisense oligonucleotide, zfahr2-MO. However, toxic effect cardiosulfa not alleviated zfcyp1a-MO, morpholino oligo cytochrome P450 1A (CYP1A), which most well-characterized gene pathway. Similar were obtained known agonist PCB126. These observations suggest causes zebrafish through AhR-mediated, CYP1A-independent Our indicate has potential novel type probe to investigate
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