Cognition-activating properties of 3-(aryloxy)pyridines

摘要: A series of 3-(aryloxy)pyridines was found to possess activity in enhancing retention for passive avoidance learning mice. This test used select compounds with potential therapeutic properties the treatment cognitive disorders. Reference drugs that gave positive results this procedure included d-amphetamine, magnesium pemoline, methyl phenidate, picrotoxin, phenytoin, and ethosuximide. All active inverted U-shaped dose-response curves. The most 3-phenoxypyridine (1), 3-(2-fluorophenoxy)pyridine (2), 3-(4-fluorophenoxy)pyridine (4), 3,3'-oxybis(pyridine) (23), 1-oxide (24). 3-Phenoxypyridine (1) clearly superior all analogues tested terms level retention, grammometric potency, breadth its curve. It given designation CI-844 after a detailed study pharmacological profile submitted preclinical toxicology.