The Thalamus Regulates Retinoic Acid Signaling and Development of Parvalbumin Interneurons in Postnatal Mouse Prefrontal Cortex

摘要: GABAergic inhibitory neurons in the prefrontal cortex (PFC) play crucial roles higher cognitive functions. Despite link between aberrant development of PFC interneurons and a number psychiatric disorders, mechanisms underlying these are poorly understood. Here we show that retinoic acid (RA)-degrading enzyme CYP26B1 (cytochrome P450 family 26, subfamily B, member 1) is transiently expressed mouse frontal during postnatal development, medial ganglionic eminence (MGE)-derived interneurons, particularly parvalbumin (PV)-expressing neurons, main cell type has active RA signaling this period. We found cortex-specific Cyp26b1 knock-out mice had an increased density PV-expressing, but not somatostatin-expressing, PFC, indicating novel role controlling PV neuron development. The initiation expression neonatal coincides with establishment connections thalamus PFC. required for In addition to region-specific regulates thalamocortical connectivity earlier radial dispersion MGE-derived throughout embryonic neocortex. summary, our results suggest plays multiple, temporally separate interneuron