Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression.
作者： M Adachi , T Taki , T Konishi , C I Huang , M Higashiyama
DOI: 10.1200/JCO.1998.16.4.1397
关键词:
摘要: PURPOSEThe transmembrane-4 superfamily (TM4SF) is a recently discovered family of genes. Of the TM4SF members, MRP-1/CD9, KAI1/CD82, and ME491/CD63 have been reported to modulate tumor progression or metastasis. In this study, we investigated relationships between these three genes, MRP-1, KAI1, ME491, in patients with non-small-cell lung cancers (NSCLCs). Moreover, assessed prognostic value evaluating expressions ME491 simultaneously NSCLCs.PATIENTS AND METHODSOne hundred seventy-two up stage IIIB NSCLC underwent radical surgery during period January 1991 through June 1994. Using quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) analysis, studied expression genes patients.RESULTSWe found that 109 (63.4%) had MRP-1-positive tumors 42 (24.4%) KAl1-positive tumors. Conversely, all 172 expressed ME491. No relationship was MRP-1 expres...
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