Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders.

摘要: Substance abuse has an enormous impact on economic and quality of life measures throughout the world. In more developed countries, overutilization most common forms substances abuse, alcohol tobacco, is addressed primarily through prevention substance use initiation secondarily treatment those with or dependence. general, these therapeutic approaches to are deemed effective. However, there a broad consensus that development additional tools aid diagnosis, prioritize selection monitor response could have substantial effectiveness both treatment. The recent demonstrations by number groups exposure associated robust changes in DNA methylation signatures peripheral blood cells suggests possibility assessments saliva find clinical applications. this article, we review progress epigenetic assessment particular emphasis smoking (and alcohol) related addition, highlight areas, such as epigenetics psychostimulant, opioid cannabis which markedly understudied benefit from intensified collaborative efforts define biomarkers