A randomized, controlled trial of high‐dose dextromethorphan in facial neuralgias. (National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD) Neurology 2000;55:964–971.

摘要: A randomized, double-blinded, crossover trial compared 6 weeks of oral dextromethorphan with active placebo (low-dose lorazepam) in 19 patients, stratified into three groups: 11 facial pain and possible trigeminal neuropathy, 5 anesthesia dolorosa, 3 idiopathic neuralgia. Dosage was titrated each patient to the highest level reached without disrupting normal activities. Patients completing included 10 4 2 In patients neuropathy decreased by a mean only 2% 4%, these estimates were not significant. Both neuralgia had more during treatment than treatment. Of who demonstrated an analgesic response main trial, 1 repeatedly responded subsequent confirmatory drug-placebo crossovers. Conclude shows little or no efficacy due dolorosa. Additional trials are necessary conclusively evaluate NMDA-receptor antagonists