Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese.

摘要: Abstract Manganese is an essential element for biological systems, nevertheless occupational exposure to high levels of Mn can lead neurodegenerative disorder, characterized by excessive accumulation, especially in astrocytes basal ganglia and symptoms closely resembling idiopathic Parkinson's disease (PD). The purpose this study was evaluate behavioral biochemical alterations adult rats exposed 30 days 10 25 mg/mL MnCl 2 their drinking water. intoxicated showed impaired locomotor activity comparison control animals. Furthermore, lipid peroxidation were increased, δ-aminolevulinate dehydratase (δ-ALA-D, enzyme sensitive pro-oxidant situations) inhibited 45 Ca 2+ influx into striatal slices decreased Mn, indicating that brain region markedly affected short-term exposure. In contrast, not associated with characteristic extrapyramidal effects did modify protein oxidation, suggesting the damage represents early stages Mn-induced damage. addition, treatment reduced body weight gain, but there no discernible liver kidney function. conclusion, caused increased oxidative stress striatum, which are likely linked activity, occurrence orofacial dyskinesia.