Leptin in the regulation of the immunometabolism of adipose tissue-macrophages.

摘要: Obesity is a pandemic disease affecting around 15% of the global population. major risk factor for other conditions, such as type 2 diabetes and cardiovascular diseases. The adipose tissue main secretor leptin, an adipokine responsible regulation food intake energy expenditure. Obese individuals become hyperleptinemic due to increased adipogenesis. Leptin acts through leptin receptor induces several immunometabolic changes in different cell types, including adipocytes Mϕs. Adipose resident Mϕs (ATMs) are largest leukocyte population these ATMs constant contact with excessive levels secreted obese conditions. activates both JAK2-STAT3 PI3K-AKT-mTOR pathways. activation pathways leads intracellular metabolic changes, glucose uptake, upregulation glycolytic enzymes, disruption mitochondrial function, well immunologic alterations, phagocytic activity proinflammatory cytokines secretion. Here, we discuss effects how hyperleptinemia can contribute low-grade systemic inflammation obesity.