Serotonin, Amygdala and Fear: Assembling the Puzzle.

摘要: The fear circuitry orchestrates defense mechanisms in response to environmental threats. This is evolutionarily crucial for survival, but its dysregulation thought play a major role the pathophysiology of psychiatric conditions humans. amygdala key player processing fear. brain area prominently modulated by neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT input has drawn particular interest because genetic and pharmacological alterations transporter (5-HTT) affect activation emotional stimuli. Nonetheless, impact on remains poorly understood.The aim this review elucidate physiological learning via action neuronal circuits amygdala. Since release increases basolateral (BLA) during both memory acquisition expression, we examine whether how neurons encode aversive stimuli cues. Next, describe neurotransmission that, rodents humans, lead altered learning. To explore through which could modulate conditioned fear, focus rodent BLA. We propose that circuit-based approach taking into account localization specific receptors neurochemically-defined BLA may be essential decipher behavior. In keeping with control learning, electrophysiological data suggesting regulates synaptic plasticity, spike synchrony theta oscillations actions different subcellular compartments principal distinct GABAergic interneuron populations. Finally, discuss recently developed optogenetic tools combined recordings behavior progress knowledge underlying modulation circuits. Such advancement pave way deeper understanding health disease.