The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks.

摘要: OB protein (also known as leptin), a previously unknown signal, is secreted from adipose tissue, circulates in the blood, probably bound to family of binding proteins, and acts on central neural networks that regulate ingestive behavior energy balance. provides communication link fat tissue brain. Rapidly accumulating evidence suggests appears play major role control body stores through coordinated regulation feeding behavior, metabolism, autonomic nervous system balance rodents, primates humans. The field has rapidly moved cloning ob gene demonstration complex expression rats humans, then potent biological activity ob/ob, diet-induced, lean mice well obese but not db/db mice. A significant milestone was our administration lead reductions food intake, weight alterations metabolism consistent with activation system. These findings were followed by identification site for labelled choroid plexus Zucker rats. receptor, OB-R, mouse soon followed. OB-R receptor found be expressed plexus, hypothalamus several peripheral tissues. exists multiple forms; two forms are short form (with truncated intracellular domain) long complete domain). thought signals mediates effects protein. Initial situ hybridization studies have demonstrated mRNA localized sites. Recently, it db encodes receptor. Evidence been provided specific transport cross blood-brain-barrier enter brain mice, rate can decreased high plasma concentrations Thus, reduced entry may one mechanisms sensitivity pathway individuals. also important neuroendocrine adaptive responses fasting reproduction. Therapeutic approaches treatment obesity based ranging injection agonists upregulation signalling pathways under intense investigation.