Bis(polysialic acid) biomimetic material and preparation method thereof
作者： Jiang Yun , Gao Minjie , Wu Jianrong , Zhan Xiaobei , Zhang Hongtao
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摘要: The invention relates to a preparation method of bis(polysialic acid) biomimetic material, comprising: subjecting PSA (polysialic reductive amination form PSA-NH2; N-acetylneuraminic acid derivatization, including deacetylation, reducing end and non-reducing an aldehyde group so as obtain aldehyde-containing polysialic derivative; linking the derivative PSA-NH2 via crosslinker N-hydroxysuccinimide active ester material CHO-Sia-(PSA)2. Theinvention also provides prepared above method. composite modified by acid), is drug protein or primary-amine-containing compound reaction under catalytic action sodium cyanoborohydride. Thebis(polysialic can decrease immunogenicity composite, enhance immunological recognition disguise-evading action, improve in-vivo stability, compatibility blood circulation time composite.
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