Antiangiogenic Targeting Liposomes Increase Therapeutic Efficacy for Solid Tumors

摘要: It is known that solid tumors recruit new blood vessels to support tumor growth, but the molecular diversity of receptors in angiogenic might also be used clinically develop better targeted therapy. In vivo phage display was identify peptides specifically target vessels. Several novel were identified as being able recognize vasculature not normal severe combined immunodeficiency (SCID) mice bearing human tumors. These tumor-homing bound surgical specimens various cancers. The peptide-linked liposomes containing fluorescent substance capable translocating across plasma membrane through endocytosis. With conjugation and liposomal doxorubicin, drug delivery systems enhanced therapeutic efficacy chemotherapeutic agent against cancer xenografts by decreasing angiogenesis increasing cell apoptosis. Furthermore, peptide-mediated targeting improved pharmacokinetics pharmacodynamics they delivered compared with nontargeting or free drugs. Our results indicate can have potential improve systemic treatment patients