Contrast-enhancing tumor growth dynamics of preoperative, treatment-naive human glioblastoma

摘要: Author(s): Ellingson, Benjamin M; Nguyen, Huytram N; Lai, Albert; Nechifor, Ruben E; Zaw, Okkar; Pope, Whitney B; Yong, William H; Nghiemphu, Phioanh L; Liau, Linda Cloughesy, Timothy F | Abstract: BackgroundLittle is known about the natural growth characteristics of untreated glioblastoma before surgical or therapeutic intervention, because patients are rapidly treated after preliminary radiographic diagnosis. Understanding uninhibited human may be useful for characterizing changes in response to therapy. Thus, objective current study was explore tumor dynamics a cohort with intervention.MethodsNinety-five who had measurable enhancing disease on g2 magnetic resonance imaging scans surgery were identified. Tumor rates quantified 4 different ways (the percentage change per day, absolute rate estimated volumetric doubling time, and radial expansion rate) using 3 approaches (bidirectional product, disease, total lesion volume).ResultsThe median time 21.1 days, volume 2.1% 0.18 cc day. The length follow-up between examinations should g28 days detect progressive high specificity. Small initial sizes (l3 cm greatest dimension) biased toward large at follow-up.ConclusionsPresurgical, treatment-naive can variety similar results. size depend baseline interval scans. Cancer 2016;122:1718-27. © 2016 American Society.