Regulation of chemoreceptor sensitivity in the carotid body: the role of presynaptic sensory nerves.

摘要: Several neural and vascular mechanisms regulate the sensitivity of carotid body chemoreceptors to hypoxia, hypercapnia, acidosis. Factors that control blood flow oxygen delivery in along with those augment or diminish catecholamine release from glomus cells can have major effects on chemoreceptor function. In addition, sensory nerves themselves may participate regulation sensitivity. A portion body's are presynaptic cells. response stimulation, nerve terminals exhibit ultrastructural changes resemble associated increased transmitter motor nerves: 1) number small (synaptic) vesicles decreases; 2) coated regions cisternal membrane increase during stimulation. If a neurotransmitters, activity could influence cell secretion catecholamines other substances tha modify Such an effect be produced by hypoxia conditions stimulate it result antidromic evoked primary afferent depolarization their CNS.