Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent
作者： Alessandra di Pietro , Roelof Koster , Wytske Boersma-van Eck , Wendy A. Dam , Nanno H. Mulder
DOI: 10.4161/CC.22803
关键词:
摘要: In murine testicular cancer (TC) cells wild-type p53 contributes to sensitivity DNA-damaging drugs in a dose-dependent way. human TC, however, the role of functionality chemotherapeutic response remains elusive. We analyzed cisplatin TC setting using short interfering (si)RNA approach. The cisplatin-sensitive cell line (Tera), subline with acquired resistance (Tera-CP) and panel intrinsically resistant lines (Scha 2102EP), all expressing p53, were used. transcriptional targets MDM2 p21Waf1/Cip1 (p21) expressed transactivation-dependent way lines. Following exposure, expression levels increased, subsequent increase p21 mRNA protein Fas membrane levels. Downregulation siRNA lowered cisplatin-induced apoptosis Tera Tera-CP, which was associated diminishe...
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