Iron intake and the risk of colorectal cancer.

摘要: Prospectively gathered data from the National Health and Nutrition Examination Survey I Evaluation Follow-Up Study were analyzed to evaluate risk of colorectal cancer due consumption iron. Morbidity mortality available on 14,407 persons first interviewed in 1971 followed through 1986. A total 194 possible cancers occurred this group over 15-year period. Subsite analysis showed that colon iron intake was elevated throughout for both men women, with highest adjusted risks interquartile range seen proximal females (relative risk, 1.51; 95% confidence interval, 1.41-1.60). The rectal not significantly or women. Elevated serum also associated increased risk; however, effect strongest distal (rather than proximal) significant only among (adjusted relative 1.73; 1.03-2.92). mean transferrin saturation higher cases controls (30.7 versus 28.7%), but iron-binding capacity did seem predict occurrence cancer. Proportional hazards models confirmed effects confounded by age, gender, energy consumption, fat intake, other known factors These suggest may confer an cancer, localization be attributable mode epithelial exposure. It seems luminal exposure increases proximally, whereas humoral distally. differences such as oxidation state, binding proteins presence cofactors bile acids, products bacterial metabolism.