Cav1 Suppresses Tumor Growth and Metastasis in a Murine Model of Cutaneous SCC through Modulation of MAPK/AP-1 Activation

摘要: Caveolin-1 (Cav1) is a scaffolding protein that serves to regulate the activity of several signaling molecules. Its loss has been implicated in pathogenesis types cancer, but its role development and progression cutaneous squamous cell carcinoma (cSCC) remains largely unexplored. Herein, we use keratinocyte line PAM212, murine model cSCC, determine function Cav1 skin tumor biology. We first show overexpression decreases growth, whereas knockdown increases these attributes PAM212 cells. In addition, invasive ability incidence spontaneous lymph node metastasis. Finally, demonstrate extracellular signaling–related kinase 1/2 mitogen-activated kinase/activator protein-1 pathway activation. attribute growth advantage conferred by increased expression activator transcriptional targets, including cyclin D1 keratin 18, which inverse based on level Cav1. summary, affects characteristics associated with aggressive human tumors this may be an important modulator invasion cSCC.