Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (from the Atherosclerosis Risk in Communities Study).
作者： Aaron Folsom , Ron C. Hoogeveen , Gerardo Heiss , Eric Boerwinkle , Amil M. Shah
DOI: 10.1016/J.AMJCARD.2021.01.017
关键词:
摘要: Membrane-bound angiotensin-converting enzyme 2 is important in regulation of the renin–angiotensin–aldosterone system, but association cleaved soluble ACE2 (sACE2) with cardiovascular disease (CVD) unclear. We evaluated sACE2 cardiac biomarkers, structure, and function events Atherosclerosis Risk Communities Study. was measured a subset 497 participants (mean age 78±5.4 years, 53% men, 27% black); Cox regression analyses assessed prospective associations time to first CVD event at median 6.1-year follow-up. higher blacks, prevalent CVD, diabetes, or hypertension. Higher levels were associated significantly biomarkers injury (high-sensitivity troponin I T, N-terminal pro–B-type natriuretic peptide), greater left ventricular mass index, impaired diastolic linear analyses, increased risk for heart failure hospitalization (adjusted hazard ratio per natural log unit increase [HR] 1.32, 95% confidence interval [CI] 1.10 1.58), (HR 1.34, CI 1.13 1.60), all-cause death 1.26, 1.01 1.57). In an elderly biracial cohort, positively reflecting myocardial neurohormonal activation, function, death.
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