Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats
作者： R.P. Webster , M.D. Gawde , R.K. Bhattacharya
DOI: 10.1016/S0304-3835(96)04443-6
关键词:
摘要: Administration of hepatocarcinogens aflatoxin B1 and N-nitrosodimethylamine to rats caused single-strand breaks in nuclear DNA. Inclusion the diet rutin, a naturally occurring phenolic flavonoid glycoside, significantly reduced appearance such breaks. The protection against DNA damage was found be reduction induction repair enzymes polymerase, polymerase beta ligase. Even associated with poly(ADP-ribose) marginal dose rutin effective this regard. Since inefficient are expected initiate process carcinogenesis, modulation by these parameters emphasizes protective role carcinogenesis induced chemical carcinogens.
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