Associations between stool micro-transcriptome, gut microbiota, and infant growth.

摘要: Rapid infant growth increases the risk for adult obesity. The gut microbiome is associated with early weight status; however, no study has examined how interactions between microbial and host ribonucleic acid (RNA) expression influence growth. We hypothesized that dynamics in stool micro-ribonucleic acids (miRNAs) would be both activity via putative metabolic targets. Stool was collected twice from 30 full-term infants, at 1 month again 6 12 months. RNA were measured high-throughput sequencing aligned to human databases. Infant by weight-for-length z-score birth Increased transcriptional of Clostridia (R = 0.55; Adj p 3.7E-2) Burkholderia -0.820, 2.62E-3) Of 25 RNAs growth, 16 miRNAs. miRNAs demonstrated significant target enrichment (Adj < 0.05) four pathways. There associations growth-related phyla. have shown longitudinal trends microbiota miRNA levels are targets suggest these molecules may regulate biosynthetic landscape activity.