Theoretical and experimental examination of particle–particle interaction effects on induced dipole moments and dielectrophoretic responses of multiple particle chains

摘要: Dielectrophoresis (DEP), an electrokinetic phenomenon based on particle polarizations in nonuniform electric fields, is increasingly employed for and cell characterizations manipulations microdevices. However, number densities are rarely varied particle-particle interactions largely overlooked, but both affect particle's effective by changing the local field, which directly impacts assembly into chains. This work examines theoretical experimental dielectrophoretic responses then presents individual chain velocities of spherical polystyrene microparticles red blood cells (RBCs) under DEP forces a modified quadruple electrode microdevice. Velocities independently compared between 1, 2, 3, 4 beads RBCs assembled chains aligned with field. Simulations induced dipole moments particles experiencing same (single point) (multiple points) fields. Experiments simulations plotting versus applied signal frequency from 1 kHz to 80 MHz. indicate differences force exerted each according position. experiments show excellent qualitative agreement; more experienced decrease response RBCs. These results advance understanding extent that multiple observed behaviors cellular diagnostic systems.