Complement Component C3 Is Required for Protective Innate and Adaptive Immunity to Larval Strongyloides stercoralis in Mice
作者： Laura A. Kerepesi , Jessica A. Hess , Thomas J. Nolan , Gerhard A. Schad , David Abraham
DOI: 10.4049/JIMMUNOL.176.7.4315
关键词:
摘要: This study examines the role of complement components C3 and C5 in innate adaptive protective immunity to larval Strongyloides stercoralis mice. Larval survival naive C3(-/-) mice was increased as compared with wild-type mice, whereas C3aR(-/-) had equivalent levels killing. killing shown be a coordinated effort between effector cells C3. There no difference C5(-/-) indicating that not required during immune response. Naive B cell-deficient killed larvae at comparable levels, suggesting activation classical pathway for immunity. Adaptive mice; thus, also completely ablated immunized even though parasite-specific IgM response developed were recruited. Protective restored by transferring untreated serum, but C3-depleted heat-inactivated serum location parasites. Finally, efficiently Therefore, development immunity, process both responses against S. stercoralis.
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