Interferon-γ and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation

摘要: Proinflammatory cytokines including interferon-γ (IFNγ), interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα) are implicated in the pathogenesis of acute graft-versus-host disease (aGVHD). Cytokine gene polymorphism is associated with functional differences cytokine regulation altered clinical performance a variety diseases. Polymorphism IFNγIntron1 microsatellite (CA)n repeat has been linked vitro IFNγ production renal transplant rejection. The IL-6−174(G/C) single nucleotide to vivo IL-6 production, juvenile chronic arthritis, This study examined potential association GVHD polymorphisms 80 sibling bone marrow (BMT) donor/recipient pairs. Patients homozygous for allele 3 had more severe (grade III-IV) aGVHD. possessing IL-6−174G trend toward higher grades aGVHD, those were likely develop (cGVHD). associations previously identified aGVHD severity-associated (TNFd IL-10−1064) reconfirmed. Logistic regression analysis confirmed recipient genotype at (odds ratio [OR] 3.92; P  = .02), IL-10−1064 (OR 4.61;  = .026) TNFd 3.29;  = .039), that cGVHD IL-6−174 4.25;  = .007), addition age, gender mismatch, underlying disease. Assessment may potentially allow accurate prediction appropriate adjustment prophylaxis, as well indicating novel areas future studies pathogenesis.