Antibacterial, antifungal and antiprotozoal activities of fungal communities present in different substrates from Antarctica

摘要: Antarctica is a pristine and extreme environment that represents unique opportunity for taxonomic, ecological biotechnological studies of the microorganisms. In present work, fungal communities rhizosphere soil Deschampsia antarctica, soil, ornithogenic marine lake sediments in Antarctic Peninsula were characterized as well their capability to produce bioactive compounds. One hundred isolates recovered identified by molecular analysis 35 different taxa 20 genera. Pseudogymnoascus sp. 1 3, Penicillium sp., Peniophora Mortierella alpina most frequent identified. All cultured ethanolic extracts, which assayed against target organisms detect antimicrobial (against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, krusei, Cladosporium sphaerospermum Paracoccidioides brasiliensis), cytotoxic breast MCF-7 renal TK-10 human tumoral cells) antiprotozoal Leishmania amazonensis Trypanosoma cruzi) activities. Among three pathogenic species, extracts showed moderate high selective antifungal activity P. brasiliensis. The extract Purpureocillium lilacinum displayed trypanocidal, antibacterial activities, but with toxicity over normal cells. Proton nuclear magnetic resonance (1H NMR) spectral indicated presence compounds containing highly functionalized aromatic ring system. Our results suggest ecosystems represent an interesting habitat isolation characterization capable producing fungus strong trypanocidal activities cells, might be used scaffold development new drugs.