Potential Drugs and Remedies for the Treatment of COVID-19: A Critical Review

作者: Fatemeh Barati , Mahdi Pouresmaieli , Elena Ekrami , Sahar Asghari , Farzad Ramezani Ziarani

DOI: 10.1186/S12575-020-00129-1

关键词:

摘要: COVID-19 disease with a high rate of contagious and highly nonspecific symptoms, is an infectious caused by newly discovered coronavirus. Most people who fall sick will experience mild to moderate symptoms such as respiratory cough, dyspnea, fever, viral pneumonia recover without any special cure. However, some others need emergency treatment get rid this widespread disease. Till now, there are numbers proposed novel compounds well standards therapeutics agent existed for other conditions seems have efficacy against the 2019-nCoV. Some which being tested MERS-CoV SARS-CoV validated that could be also efficient new currently no effective specific antivirals or drug combinations introduced 2019-nCoV specifically supported high-level evidence. The main purpose paper review typical ongoing treatments coronavirus including home remedies, herbal medicine, chemical drugs, plasma therapy, vaccinies. In regards, famous medicines common drugs routinely prescribed patients introduced. Moreover, section assigned interactions outdated been proved inefficient. We hope work pave way researchers develop faster more reliable methods earlier rescue people.

参考文章(110)
Dianna M. Blau, Kathryn V. Holmes, Human coronavirus HCoV-229E enters susceptible cells via the endocytic pathway. Advances in Experimental Medicine and Biology. ,vol. 494, pp. 193- 198 ,(2001) , 10.1007/978-1-4615-1325-4_31
Anthony R. Fehr, Stanley Perlman, Coronaviruses: An Overview of Their Replication and Pathogenesis Methods of Molecular Biology. ,vol. 1282, pp. 1- 23 ,(2015) , 10.1007/978-1-4939-2438-7_1
Maria Grazia Lampugnani, Luca Bravi, Elisabetta Dejana, The role of microvascular endothelial WNT signaling the formation of the blood brain barrier. SpringerPlus. ,vol. 4, pp. 1- 32 ,(2015) , 10.1186/2193-1801-4-S1-L47
Samantha Cooray, Li Jin, Jennifer M Best, The involvement of survival signaling pathways in rubella-virus induced apoptosis Virology Journal. ,vol. 2, pp. 1- 12 ,(2005) , 10.1186/1743-422X-2-1
Y.O.Y. Soo, Y. Cheng, R. Wong, D.S. Hui, C.K. Lee, K.K.S. Tsang, M.H.L. Ng, P. Chan, G. Cheng, J.J.Y. Sung, Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clinical Microbiology and Infection. ,vol. 10, pp. 676- 678 ,(2004) , 10.1111/J.1469-0691.2004.00956.X
Ivan FN Hung, Kelvin KW To, Cheuk-Kwong Lee, Kar-Lung Lee, Wing-Wa Yan, Kenny Chan, Wai-Ming Chan, Chun-Wai Ngai, Kin-Ip Law, Fu-Loi Chow, Raymond Liu, Kang-Yiu Lai, Candy CY Lau, Shao-Haei Liu, Kwok-Hung Chan, Che-Kit Lin, Kwok-Yung Yuen, None, Hyperimmune IV Immunoglobulin Treatment: A Multicenter Double-Blind Randomized Controlled Trial for Patients With Severe 2009 Influenza A(H1N1) Infection Chest. ,vol. 144, pp. 464- 473 ,(2013) , 10.1378/CHEST.12-2907
Jesse J. Kwiek, Timothy A. J. Haystead, Johannes Rudolph, Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines Biochemistry. ,vol. 43, pp. 4538- 4547 ,(2004) , 10.1021/BI035923W
M A Khamashta, G Ruiz-Irastorza, M Ramos-Casals, P Brito-Zeron, Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review Annals of the Rheumatic Diseases. ,vol. 69, pp. 20- 28 ,(2010) , 10.1136/ARD.2008.101766
Masakazu Kono, Koichiro Tatsumi, Alberto M. Imai, Kengo Saito, Takayuki Kuriyama, Hiroshi Shirasawa, Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK. Antiviral Research. ,vol. 77, pp. 150- 152 ,(2008) , 10.1016/J.ANTIVIRAL.2007.10.011
Andrea Savarino, Livia Di Trani, Isabella Donatelli, Roberto Cauda, Antonio Cassone, New insights into the antiviral effects of chloroquine Lancet Infectious Diseases. ,vol. 6, pp. 67- 69 ,(2006) , 10.1016/S1473-3099(06)70361-9