Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

摘要: Expression of proteins associated with immune function was investigated immunohistochemically in postmortem brain and spinal cord patients amyotrophic lateral sclerosis (ALS). Reactive microglia/macrophages displaying high levels leukocyte common antigen (LCA), the immunoglobulin receptor Fc gamma R1, lymphocyte molecule-1 (LFA-1), complement receptors CR3 CR4, class II major histocompatibility complex molecules HLA-DR, HLA-DP HLA-DQ determinants I HLA-A,B,C were abundant affected areas ALS. These included primary motor cortex, nuclei stem, anterior horn cord, full extent corticospinal tract. A significant number T lymphocytes helper/inducer (CD4+) cytotoxic/suppressor (CD8+) subtypes observed marginating along walls capillaries venules extending into parenchyma areas. Clusters activated oligodendroglia as well degenerating neurites positive for C3d C4d frequently detected ALS-affected data provide evidence immune-effector changes They are consistent an autoimmune or slow virus theory disorder, but may reflect only secondary changes.