Structural selection in G-quartet-based hydrogels and controlled release of bioactive molecules.

摘要: A guanosine-5'-hydrazide can entrap biologically interesting molecules such as acyclovir, vitamin C, and vancomycin into its hydrogel network. Controlled release of these was monitored by 1H NMR spectroscopy. The hydrazide may potentially form mixed G-G quartets with analogous compounds containing a guanine group. spectroscopy used to study the inclusion various derivatives hydrogel. structural selectivity found depend strongly on both shape charge additive arise from strong cohesion supramolecular architecture gel resulting resistance perturbation foreign bodies. Hydrogels thus offer promising medium for highly selective, controlled bioactive substances.