Intervention of GI neuropeptides in pancreatic growth and regeneration: comparison with cholecystokinin.

摘要: The pancreatic gland has an enormous potential for growth and regeneration, mainly in rodents. These processes remain mostly under the control of GI hormone cholecystokinin (CCK). human pancreas however does not show proliferative properties after partial pancreatectomy, but research this field been scarce. Recent studies indicate that CCK might be expected trophic agent since its two receptors A Β were found on exocrine pancreas. Therefore, if grows regenerates, it to influence some unknown factors. Neuropeptides receiving much attention lately as regulators functions could among searched agents. This presentation focusses neuropeptides potential: GRP-Bombesin, GABA, PP, PYY, Neurotensin, SP, VIP, PACAP, CGRP galanin. Some have moderate effects enzymes electrolytes secretion: PACAP. However, their unexplored except GRP-bombesin PACAP preferentially exhibits mitogenic acinar cells AR4-2J via tyrosine kinase, phospholipase D ornithine decarboxylase activation through adenylate cyclase. promoting action is well documented rodent's recent neuropeptide potentially larger mammals' Indeed, investigators recently bombesin induced regeneration pig pancreatectomy mitogen-activated protein kinases do CCK-8 caerulein rat Have we magic factor large mammals? Further investigations will tell.