Protein Kinase C as a Sensor for Oxidative Stress in Tumor Promotion and Chemoprevention

摘要: Protein kinase C (PKC) has emerged as a key enzyme that is activated by transmembrane signals such products of phospholipid hydrolysis and Ca2+.1-5 PKC represents family more than 11 isoenzymes, which are divided broadly into Ca2+-dependent type (α,β,γ) Ca2+-independent (δ,e,ζ, etc.).1-5 Differences in the subcellular localization well expression these isoenzymes various cell types, enable isoenzyme system to respond differentially wide variety cellular stimuli.1-5 The experimental tumor promoters, phorbol esters, bind activate PKC., results increased membrane association (translocation) ultimately leads its down-regulation. also inactivated oxidant promoters play an important role carcinogenesis human settings.6-10 unique structural aspects make it suitable target for redox-sensitive cancer chemopreventive agents (antioxidants) growth-inhibiting natural products.11 This been shown influence properties motility, adhesion, invasion, metastasis, therefore involved not only promotion but later events related progression.12-15 crucial currently targeted development agents, antiproliferative, antimetastatic agents.