MSRV Pol sequence copy number as a potential marker of multiple sclerosis
作者： Danuta Januszkiewicz-Lewandowska , Mieczysław Wender , Jolanta Rembowska , Jerzy Nowak , Hanna Hertmanowska
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摘要: Multiple sclerosis (MS) is a neurological disease in which demyelination the brain and spinal cord observed. The causal influence of bacterial/viral infections genetic/immune factors etiology multiple suggested. sclerosis-related retrovirus (MSRV) one potential agents, can lead to development disease. aim cytogenetic studies was assessment MSRV pol sequence copy number patients with MS compared normal individuals. Cytogenetic slides interphase nuclei extended chromatin fibers were prepared from peripheral blood 16 10 healthy Fluorescence situ hybridization (FISH) biotinylated product polymerase chain reaction used order analyze examined material. Detection probe carried out by immunological avidin-fluorescein anti-avidin. significantly greater than Using FISH technique fibers, it observed that exists as tandem repeats on various chromosomes. increased has been found controls.
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