Roles of phosphoinositide-specific phospholipase Cγ1 in brain development

摘要: Over the past decade, converging evidence suggests that PLCγ1 signaling has key roles in controlling neural development steps. functions as a signal transducer converts an extracellular stimulus into intracellular signals by generating second messengers such DAG and IP3. activator of either PKC or transient receptor potential cation channels (TRPCs), while IP3 induces calcium release from stores. These regulate morphological change neuron, neurite outgrowth, migration, axon pathfinding, synapse formation. changes depend on finely tuned following tyrosine kinase-mediated signaling. Thus, deregulation causes various abnormalities neuronal it may be associated with diverse neurological disorders. Herein, we discuss current understanding pathway provide recent advances how is involved formation processes for functionally faithful brain development.