G-quartet-induced nanoparticle assembly.

摘要: The design and synthesis of a new class gold nanoparticle with guanosine monophosphate derivatives or G-rich oligonucleotides as their surface ligands are described. These nanoparticles spontaneously form macroscopic assemblies at low temperature relatively high salt concentrations, which is attributed to the cooperative formation quartets G-quadruplexes between individual nanoparticles. Significantly, solution behavior these highly controllable by adjusting parameters (including temperature, ionic strength, ion species) sequence oligonucleotide