[Hematologic toxicity of Gynura segetum and effects on vascular endothelium in a rat model of hepatic veno-occlusive disease].

摘要: Objective To observe the effects of Gynura segetum in rats with hepatic veno-occlusive disease (HVOD). Methods Sixty Sprague-Dawley were assigned to a blank control group, one three treatment groups (low-dose 5.0 g/kg; mid-dose 10 high-dose 20 g/kg), or pseudo-drug group (10 g/kg pseudo-ginseng). After 28 days treatment, on white blood cell count, coagulation, secreted factors from vascular endothelium, and histopathology spleen observed inter-group differences statistically assessed. Results After 4-week administration, all showed decrease body weight, increases numbers leukocytes, neutrophils, lymphocytes, monocytes eosinophils. decreases platelets platelet hematocrit, mean volume distribution. In addition, treatments increased prothrombin time, activated partial thromboplastin thrombin ratio international normalized ratio, but decreased PT%, fibrinogen level aggregation. Serum levels endothelin nitric oxide also elevated by treatments. All measured parameters significant (P<0.01 <0.05). Finally, splenic follicles significantly reduced spleens an absence germinal centers along large number diffuse lymphocytes red pulp sinusoids. Conclusion The has some toxic effects; it can reduce count inhibit clotting time aggregation, increase secretion endothelium disrupt histology. Key words: Gynura segetum; Composite family; Hepatic venular occlusive disease; Hematologic toxicity; Secretion endothelial