The chorioretinal damage caused by different half parameters of photodynamic therapy in rabbits.
作者： Lan-Hsin Chuang , Yih-Shiou Hwang , Nan-Kai Wang , Yen-Po Chen , Laura Liu
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摘要: Abstract Purpose: To compare the chorioretinal tissue response after different half-strength parameters of photodynamic therapy (PDT) in rabbits. Methods: The study included 4 groups, and each group contained animals. full dose served as control group: verteporfin (4 mg/kg) with 600 mW/cm2 irradiance from a diode laser at 689 nm applied to retina for 8 s. One parameter was changed other 3 groups. HLaser received irradiance. HTime exposed photosensitization half time, HDose drug dose. Six spots were generated eyes every rabbit documented graphically. lesions examined on days 1, 7, 42 PDT treatment using color fundus imaging, fluorescein angiography (FA), histopathology analysis. Results: rabbits caused damage all FA day 1 showed that use irradiance, do...
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