Aspergillus and Aspergillosis

摘要: Species of aspergilli are common in man's environment and responsible for a wide spectrum human animal disease, ranging animals from mycotic abortion to aflatoxicosis humans localized colonization the ear or skin life-threatening systemic infection neutropenic patients. In recent times, invasive aspergillosis has become increasingly important as cause morbidity death, initially patients receiving immunosuppression prior organ transplantation, latterly haematologic rendered by underlying disease chemotherapy. some centres, condition been recorded more than 40% dying with acute leukaemia. Laboratory diagnostic procedures not always helpful diagnosis depends largely on clinical parameters. The clinician is faced yet another problem, that management. At present, antifungal therapy can be ineffectual, mortality rate remains unacceptably high. Since Aspergillus fumigatus was first described almost 125 years ago, several other pathogenic species have recognized. marked biosynthetic abilities varied mechanisms gene recombination long commanded attention food technology genetics. Their equally attracted interest toxicologists, allergists physicians concerned infectious diseases.