Sedentary behavior and mortality in older women: the Women's Health Initiative.

摘要: Background Although epidemiologic studies have shown associations between sedentary behavior and mortality, few focused on older women with adequate minority representation controlled for both physical activity functional status. Purpose The objective of this study was to determine the relationship time total; cardiovascular disease (CVD); coronary heart (CHD); cancer mortality in a prospective, multiethnic cohort postmenopausal women. Methods population included 92,234 aged 50–79 years at baseline (1993–1998) who participated Women's Health Initiative Observational Study through September 2010. Self-reported assessed by questionnaire examined 4 categories (≤4, >4–8, ≥8–11, >11 hours). Mortality risks were using Cox proportional hazard models adjusting confounders. Models also stratified age, race/ethnicity, body mass index, activity, function, chronic examine possible effect modification. Analyses conducted 2012–2013. Results mean follow-up period 12 years. Compared reported least time, reporting highest had increased risk all-cause multivariate model (HR=1.12, 95% CI=1.05, 1.21). comparing versus lowest CVD, CHD, as follows: HR=1.13, CI=0.99, 1.29; HR=1.27, CI=1.04, 1.55; HR=1.21, CI=1.07, 1.37, respectively. For all outcomes, there significant linear tests trend. Conclusions There greater amounts after controlling multiple potential