Modulation of 1,2-Dichlorobenzene Hepatotoxicity in the Fischer-344 Rat by a Scavenger of Superoxide Anions and an Inhibitor of Kupffer Cells

摘要: Abstract The hepatotoxicity of 1,2-dichlorobenzene (l,2-DCB) was studied in Fischer-344 (F344) rats administered methyl palmitate (MP) to inhibit Kupffer cell function or superoxide dismutase (conjugated polyethylene glycol, i.e., PEG-SOD) scavenge anions. In not pretreated with phenobarbital (PB), administration either MP PEG-SOD dramatically reduced the severity 1,2-DCB-induced liver injury. Both agents elevations plasma ALT activities by 80%. conferred protection when 2 hr before after 1,2-DCB. Light microscopic examination H & E-stained sections confirmed that reductions reflected from hepatocellular Interestingly, did protect against PB-pretreated rats. degree inhibition 1,2-DCB animals also less than normal and significantly different. lack a significant PB-potentiated both suggests reactive oxygen species released nonparenchymal source were as crucial Our results using support hypothesis cells play major role progression F344 rat.