Vitamin D: Actions for the new millennium.

摘要: The past two decades have witnessed new facets in vitamin D metabolism. Free D3 till now considered to be limited animal sources, has been shown occur plants. Further, the extrarenal synthesis of active or calcitriol documented physiological as well certain pathological conditions. At cellular level, acts through a dual mechanism. genomic pathway involves receptor (VDR) which is ubiquitous distribution and linked with various diseases. Besides, nongenomic VDR—independent also exists. biological effects can no longer dismissed by merely referring calcium/bone homeostasis. It enhances perinatal growth suppresses abnormal growth, well. on endocrine, immune, cardiovascular, reproductive nervous systems characterized. compelling believe that and/or its analogues will find extensive applications at least treatment osteoporosis, retardation, neoplasia, psoriasis, insulin resistance transplantation.