Antidepressant-associated mania: a controlled comparison with spontaneous mania.

摘要: OBJECTIVE: Antidepressants have been associated with the induction of mania and rapid cycling. This study examined whether antidepressant-associated manic states differ in any way from spontaneous mania. METHOD: Forty-nine consecutive inpatients were compared 49 matched a blind, retrospective chart review. RESULTS: Across virtually every clinical measure examined, patients experienced milder more time-limited episodes than The subject to frequent checking by nurses hall restriction for significantly shorter period time also had less severe levels delusions, hallucinations, psychomotor agitation, bizarre behavior, according standard rating instrument, For further divided into subgroups taking four individual classes antidepressant drugs: tricyclics (N = 19), fluoxetine 13), monoamine oxidase inhibitors (MAOIs) 8), bupropion 6); three combinations drugs not included these analyses. MAOI- bupropion-associated slightly lower overall severity psychopathology at admission fluoxetine- tricyclic-associated CONCLUSIONS: Antidepressant-associated appears be syndrome may represent distinct entity. MAOIs either tricyclic or fluoxetine. Language: en