Mechanisms of clinical resistance to 5-fluorouracil chemotherapy

摘要: In the late 1950s, era of fluoropyrimidine antimetabolite chemotherapy was ushered in with synthesis 5-fluorouracil (5-FU) by Heidelberger and colleagues [1]. The rationale for development this class compounds arose from studies that showed preferential utilization nucleobase uracil nucleic acid biosynthesis rat hepatoma cells when compared normal intestinal mucosa [2]. view finding fact profound biological effects had been observed upon substitution fluorine hydrogen several classes compounds, it postulated fluorine-substituted pyrimidine analogs might display selective antitumor activity.