Stereotactic Radiotherapy for Pulmonary Oligometastases: A Systematic Review

摘要: Introduction Hypofractionated stereotactic body radiotherapy (SBRT) is an emerging noninvasive technique for the treatment of oligometastatic cancer. The use small numbers large doses, should in theory, achieve high rates local control. aim this literature review to critically assess SBRT pulmonary metastases as judged by its effect on control, survival, and toxicity. Methods A systematic search was performed. Both single fraction radiosurgery (SRS) hypofractionated were considered individually. Thirteen institutions reported results regarding seven SRS (a total 29 publications). Outcomes, techniques, radiobiology, scientific rigor studies analyzed. Results wide range dose fractionation schedules found. Three hundred thirty-four patients with 564 targets series. 2-year weighted control 77.9%. corresponding overall survival 53.7%, a 4% rate grade 3 or higher radiation toxicities. One fifty-four 174 treated 78.6%. 50.3%, 2.6% Conclusion There insufficient evidence recommend consensus view optimal tumor parameters, fractionation, technical delivery treatment. This indicates need further prospective studies. However, that could potentially lead benefit justifies consideration limited oligometastases.