Animal models of multiple sclerosis: the good, the bad and the bottom line

摘要: Multiple sclerosis (MS) is a spontaneous, acquired, inflammatory demyelinating disease of the human CNS. Because it involves complex interaction between two most intricate biological systems, immune system and CNS, animal modeling has been critical for addressing MS pathogenesis. models were originally developed serendipitously more than 75 years ago. Immune-mediated, toxic, viral genetic demyelination are now used to understand manifold aspects MS. treatments evolved in part from model research, further progress envisaged large because these systems have continually refined their use focused on questions whose relevance was established by studying disease.