Adenosine-cannabinoid receptor interactions. Implications for striatal function.

摘要: Adenosine and endocannabinoids are very ubiquitous non-classical neurotransmitters that exert a modulatory role on the transmission of other more ‘classical’ neurotransmitters. In this review we will focus their common as modulators dopamine glutamate neurotransmission in striatum, main input structure basal ganglia. We pay particular attention to adenosine A2A receptors cannabinoid CB1 receptors. Experimental results suggest presynaptic interacting with cortico-striatal glutamatergic terminals make synaptic contact dynorphinergic medium-sized spiny neurons (MSNs) involved motor-depressant addictive effects cannabinoids. On hand, postsynaptic D2 dendritic spines enkephalinergic MSNs MSN probably cataleptogenic These receptor interactions most depend existence variety heteromers A2A, different elements striatal spine modules. Drugs selective for could be used treatment neuropsychiatric disorders drug addiction they provide effective drugs fewer side than currently drugs. This article is part themed issue Cannabinoids. To view editorial visit http://dx.doi.org/10.1111/j.1476-5381.2010.00831.x