Curcumin attenuates oxidative stress-induced altered histoarchitecture of testes in experimentally exposed rats to metal mixture (lead, arsenic, cadmium, mercury, iron, and copper) for 28 days

摘要: This study was undertaken to assess the toxicity of mixture six metals including lead (Pb), arsenic (As), cadmium (Cd), mercury (Hg), iron (Fe), and copper (Cu) at environmentally realistic concentrations determine whether curcumin able prevent testicular injury in rats. Forty-two rats were divided into seven groups, animals/group: control (water), vehicle (groundnut oil), (100 mg/kg body wt.), 10x mixture, 100x plus curcumin, curcumin. At end exposure period 28 days, sacrificed testes collected for analysis oxidative stress markers, enzymes, histopathology. dose, % weight gain significantly reduced compared control, accompanied by decreased absolute group; however, relative among groups did not show any significant difference. Exposure elevated levels lipid peroxidation products; whereas, catalase...