Evidence that the effect of bicycle exercise on blood mononuclear cell proliferative responses and subsets is mediated by epinephrine

作者: N. Tvede , M. Kappel , K. Klarlund , S. Duhn , J. Halkjœr-Kristensen

DOI: 10.1055/S-2007-1021028

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摘要: The present study was designed to test the hypothesis that exercise-induced changes in blood mononuclear cell (BMNC) subsets, BMNC proliferative responses and lymphokine activated killer (LAK) activity are mediated by increased epinephrine concentrations. Healthy male volunteers 1) exercised on a bicycle ergometer (75% of VO2max, 1 h) 2) another day were given as an intravenous infusion obtain plasma concentrations comparable with those seen during exercise. Blood samples collected basal state, last minutes exercise or 2 h later. During both perturbations %CD3+ %CD4+ T cells declined %CD16+ NK increased. Two afterwards CD14+ monocytes increased, while no observed %CD8+ %CD20+ B cells. phytohemagglutinin (PHA) response experiments. interleukin-2 (IL-2) effect proliferation cytotoxic (LAK activity) more pronounced experiments than epinephrine. Exercise caused increase lymphocytes neutrophils, but results indicate that, physical exercise, rise may contribute cellular immunity.

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