The effect of purple rice (Oryza sativa L. indica) extract on the inflammatory response in a colon cancer cell line and dextran sulfate-induced tumor promotion in the rat colon
作者： Warunyoo Phannasorn , Chakkrit Khanaree , Ariyaphong Wongnoppavich , Teera Chewonarin
DOI: 10.1007/S13273-017-0047-0
关键词:
摘要: This study investigated the effects of purple rice extract (PRE ) on inflammation-related colon carcinogenesis. Administration PRE 1 g/kg bodyweight reduced both number (39.05%) and size aberrant crypt foci (ACF) (14.28%) in colons rats that received dimethylhydrazine (DMH) initiation with promotion by dextran sulfate sodium (DSS) (P<0.05) reduction TNF-α expression colonic epithelial cells. On other hand, could suppress IL-6 RAW 264.7 cells activated lipopolysaccharide (LPS) at mRNA protein levels. Moreover it reduce IL-1β inflamed HT-29. These findings suggested is able to modulate inflammatory process macrophages cancer Therefore, suppressed macrophage activation cell line response inflammation modulated induced ACF progression rat colon.
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