Molecular Genetics of Anxiety

摘要: Anxiety is a normal response to threatening situation. When anxiety excessive and disturbs daily life functioning, it can be diagnosed as an disorder. disorders are typical complex that triggered by environmental factors in genetically susceptible individuals. Genetic variants many genes have been shown predispose disorders, but the results difficult replicate, most likely due small effect size of individual variants. evolutionarily conserved response, therefore fairly reliably modelled rodents. Quantitative trait locus mapping functional genomics proteomics approaches mouse models led identification novel pathways involved regulation anxiety-like behaviour. Some these expected regulate humans well, them might disorders. Key Concepts: Anxiety diseases individuals. Genetic identified candidate gene genome-wide association studies. The susceptibility for seems small. Features human well animals, different revealed behaviour. Combined information from several approaches, including genetics, genomics, proteomics, epigenetics neuroimaging reveal molecular mechanisms anxiety. Keywords: anxiety; linkage; genetic association; candidate gene; gene expression; personality trait; mouse model; stress