Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

作者: Eleonore Beurel , Steven F. Grieco , Richard S. Jope

DOI: 10.1016/J.PHARMTHERA.2014.11.016

关键词:

摘要: Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

参考文章(306)
Jessica L Buescher, Leigh C Zeidner, Christopher J Phiel, A novel interaction between Glycogen Synthase Kinase-3α (GSK-3α) and the scaffold protein Receptor for Activated C-Kinase 1 (RACK1) regulates the circadian clock International journal of biochemistry and molecular biology. ,vol. 2, pp. 318- 327 ,(2011)
Ana Martinez, Daniel I. Perez, GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease? Journal of Alzheimer's Disease. ,vol. 15, pp. 181- 191 ,(2008) , 10.3233/JAD-2008-15204
Eléonore Beurel, Marjelo A Mines, Ling Song, Richard S Jope, Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development Bipolar Disorders. ,vol. 14, pp. 822- 830 ,(2012) , 10.1111/BDI.12023
Armen S. Manoukian, James R. Woodgett, Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways Advances in Cancer Research. ,vol. 84, pp. 203- 229 ,(2002) , 10.1016/S0065-230X(02)84007-6
Günter U Höglinger, Hans‐Jürgen Huppertz, Stefan Wagenpfeil, María V Andrés, Vincente Belloch, Teresa León, Teodoro Del Ser, TAUROS MRI Investigators, JC Gmez, B Tijero, R Villoria, J García de Yebenes, JL Lopez Sendón, E Tolosa, MT Buongiorno, N Bargalló, JA Burguera, I Martinez, J Ruiz‐Martínez, J Villanua, F Vivancos, I Ybot, M Aguilar, JL Dolz, M Boada, A Lafuente, MA Tejero, JJ López‐Lozano, M Mata, A Kupsch, A Lipp, M Höllerhage, WH Oertel, G Respondek, M Stamelou, S Knake, D Berg, W Maetzler, KK Srulijes, A Gröger, A Ludolph, J Kassubek, M Steiger, K Tyler, DJ Burn, L Morris, A Lees, H Ling, L Strycharczuk, None, Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial. Movement Disorders. ,vol. 29, pp. 479- 487 ,(2014) , 10.1002/MDS.25815
Teodoro del Ser, Klaus C. Steinwachs, Hermann J. Gertz, María V. Andrés, Belén Gómez-Carrillo, Miguel Medina, Joan A. Vericat, Pilar Redondo, David Fleet, Teresa León, Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study. Journal of Alzheimer's Disease. ,vol. 33, pp. 205- 215 ,(2012) , 10.3233/JAD-2012-120805
K. Hughes, E. Nikolakaki, S.E. Plyte, N.F. Totty, J.R. Woodgett, Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. The EMBO Journal. ,vol. 12, pp. 803- 808 ,(1993) , 10.1002/J.1460-2075.1993.TB05715.X
Eduardo Tolosa, Irene Litvan, Günter U Höglinger, David Burn, Andrew Lees, María V Andrés, Belén Gómez‐Carrillo, Teresa León, Teodoro Del Ser, TAUROS Investigators, JC Gómez, B Tijero, K Berganzo, J García de Yebenes, JL Lopez Sendón, G Garcia, E Tolosa, MT Buongiorno, N Bargalló, JA Burguera, I Martinez, J Ruiz‐Martínez, I Narrativel, F Vivancos, I Ybot, M Aguilar, P Quilez, M Boada, A Lafuente, I Hernandez, JJ López‐Lozano, M Mata, A Kupsch, A Lipp, G Ebersbach, T Schmidt, K Hahn, G Höglinger, M Höllerhage, WH Oertel, G Respondek, M Stamelou, H Reichmann, M Wolz, C Schneider, L Klingelhöfer, D Berg, W Maetzler, KK Srulijes, A Ludolph, J Kassubek, M Steiger, K Tyler, DJ Burn, L Morris, A Lees, H Ling, R Hauser, T McClain, D Truong, S Jenkins, I Litvan, D Houghton, J Ferrara, Y Bordelon, A Gratiano, L Golbe, M Mark, R Uitti, J Ven Gerpen, None, A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy Movement Disorders. ,vol. 29, pp. 470- 478 ,(2014) , 10.1002/MDS.25824
Lian Mai, Richard S. Jope, Xiaohua Li, BDNF-mediated signal transduction is modulated by GSK3β and mood stabilizing agents Journal of Neurochemistry. ,vol. 82, pp. 75- 83 ,(2002) , 10.1046/J.1471-4159.2002.00939.X