Effect of tyrosine kinase inhibitors on wound healing and tissue repair: implications for surgery in cancer patients.

摘要: Small-molecule tyrosine kinase inhibitors (TKIs) represent a major advance in the treatment of certain forms cancer. Unexpectedly, however, their use is associated with serious toxic effects on many vital organs and functions. Some these effects, such as venous thromboembolism, haemorrhage, gastric perforation potential for impaired tissue healing, have direct implications safety surgery cancer patients. A number currently approved TKIs are suspected or been reported to impair wound healing but, understandably, there no formal pre- post-approval clinical trials evaluate extent risk. Consequently, drug labels typically recommend discontinuation TKI concerned prior elective surgery. In patients perforation, permanent advised. These recommendations, which based precautionary principle, raise dilemma, especially TKI-responsive tumours. This review focuses labelled novel antineoplastic agents repair evidence concerning likely mechanisms involved. At present, because lack data, evidence-based guidelines management treated TKIs. There need central registry outcomes following emergency receiving TKI-naive matched controls. Analysis data from registries will assist formulating TKI-treated If shown significantly therapy require special monitoring collaborative approach between oncologists surgeons individualized reappraisal risk/benefit treatment.