Haemophilus influenzae sialyltransferase and methods of use thereof

作者: Paul Jones , Nancy Phillips , Michael Apicella , Bradford Gibson

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摘要: The present invention is directed to sialytransferases, such as SiaA sialytransferases isolated from Haemophilus influenzae . Further provided herein are methods for producing sialylated lipooligosaccharides, vaccines, and host cells systems the production of lipooligosaccharides.

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Bradford W. Gibson, Michael A. Apicella, Nancy J. Phillips, Production of complex carbohydrates ,(2000)
Anthony P. Moran, Martina M. Prendergast, Ben J. Appelmelk, Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease Fems Immunology and Medical Microbiology. ,vol. 16, pp. 105- 115 ,(1996) , 10.1111/J.1574-695X.1996.TB00127.X